Cat:pGMAD000548
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMAD000548
Gene Name
Hdac3
Product Name
Accession Number
NM_010411
Gene ID
15183
Species
house mouse
Product Type
Adenovirus plasmid
Insert Length
1287
Gene Alias
Enables chromatin DNA binding activity and protein deacetylase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including histone H4-K12 deacetylation; negative regulation of cardiac muscle cell differentiation; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
EGFP
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Maker
EGFP
Regulation
overexpression
