Norway rat Mdm2 Lentivirus plasmid
Cat:pGMLV000678
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMLV000678
Gene Name
Mdm2
Product Name
Norway rat Mdm2 Lentivirus plasmid
Accession Number
NM_001108099.1
Gene ID
314856
Species
Norway rat
Product Type
Lentivirus plasmid
Insert Length
1377
Gene Alias
Enables p53 binding activity; signaling receptor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of proteolysis; and response to alkaloid. Located in several cellular components, including cytosol; nucleus; and synapse. Used to study ichthyosis; post-traumatic stress disorder; and transient cerebral ischemia. Biomarker of breast cancer; intermittent claudication; liver disease; pancreatitis; and priapism. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; glioblastoma; hepatocellular carcinoma; pancreatic ductal carcinoma; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
PURO
Fusion Tag
Null
Promoter
CMV
Resistance
Amplicin
gene description
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Maker
PURO
Regulation
overexpression
