Pre-made Cabiralizumab benchmark antibody ( Whole mAb, anti-CSF1R therapeutic antibody, Anti-FMS/CSFR/FIM2/HDLS/C-FMS/CD115/HDLS1/CSF-1R/BANDDOS/M-CSF-R Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Cabiralizumab biosimilar, Whole mAb, Anti-CSF1R Antibody: Anti-FMS/CSFR/FIM2/HDLS/C-FMS/CD115/HDLS1/CSF-1R/BANDDOS/M-CSF-R therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Cabiralizumab is developed as a monoclonal antibody antagonist targeted CSF1R, with potential antineoplastic activity. Upon administration, the drug inhibits the binding of CSF1R to CSF1 and interleukin-34 (IL-34) via binding to CSF1R expressed on monocytes, macrophages, and osteoclasts competitively.
| Products Name (INN Index) | Pre-Made Cabiralizumab biosimilar, Whole mAb, Anti-CSF1R Antibody: Anti-FMS/CSFR/FIM2/HDLS/C-FMS/CD115/HDLS1/CSF-1R/BANDDOS/M-CSF-R therapeutic antibody |
|---|---|
| INN Name | Cabiralizumab |
| Target | CSF1R |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG4 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2015 |
| Year Recommended | 2016 |
| Companies | Apexigen,Bristol-Myers Squibb,Five Prime Therapeutics,University of Chicago,Yale University |
| Conditions Approved | NA |
| Conditions Active | Pancreatic cancer,Pigmented villonodular synovitis,Cancer,Malignant melanoma,Non-small cell lung cancer,Renal cell carcinoma,Solid tumours |
| Conditions Discontinued | Rheumatoid arthritis |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | CSF1R |
| Package |
