Pre-made Fresolimumab benchmark antibody ( Whole mAb, anti-TGFB/TGFB1 therapeutic antibody, Anti-CED/DPD1/IBDIMDE/LAP Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Fresolimumab biosimilar, Whole mAb, Anti-TGFB/TGFB1 Antibody: Anti-CED/DPD1/IBDIMDE/LAP therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Fresolimumab (GC1008) is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer (kidney cancer and melanoma).
| Products Name (INN Index) | Pre-Made Fresolimumab biosimilar, Whole mAb, Anti-TGFB/TGFB1 Antibody: Anti-CED/DPD1/IBDIMDE/LAP therapeutic antibody |
|---|---|
| INN Name | Fresolimumab |
| Target | TGFB1 |
| Format | Whole mAb |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IgG4 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-I |
| Est. Status | Discontinued |
| 100% SI Structure | None |
| 99% SI Structure | 3eo0:DC:BA/4kxz:JI:HL:NM:QP/4kv5:EF:GK:HL:JI/3eo1:BA:ED:KJ:HG |
| 95-98% SI Structure | None |
| Year Proposed | 2009 |
| Year Recommended | 2010 |
| Companies | Cambridge Antibody Technology,Baylor College of Medicine,Genzyme Corporation,Sanofi Genzyme |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | Fibrosis,Malignant melanoma,Pulmonary fibrosis,Renal cancer,Focal segmental glomerulosclerosis,Osteogenesis imperfecta |
| Development Tech | CAT Phage Display |
| Previous Name | NA |
| Gm Offical Target Name | TGFB |
| Package |
