No products in the cart.
human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-X-C motif) ligand 14 (CXCL14) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Cat:GM-Tg-hg-SE0135-Ag-1
* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry
Description
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-X-C motif) ligand 14 (CXCL14) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine). Mature CXCL14 has many of the conserved features of the CXC chemokine subfamily but has some differences too, such as a shorter N-terminus and five extra amino acids in the region between its third and fourth cysteines. CXCL14 is constitutively expressed at high levels in many normal tissues, where its cellular source is thought to be fibroblasts. However, it is reduced or absent from most cancer cells. This chemokine is chemotactic for monocytes and can activate these cells in the presence of an inflammatory mediator called prostaglandin-E2 (PGE2). It is also a potent chemoattractant and activator of dendritic cells, is implicated in homing of these cells, and can stimulate the migration of activated NK cells. CXCL14 also inhibits angiogenesis, possibly as a result of its ability to block endothelial cell chemotaxis. The gene for CXCL14 contains four exons and is located on chromosome 5 in humans.
Target Information
Target Name
CXCL14
Full name
chemokine (C-X-C motif) ligand 14
Gene ID
https://www.ncbi.nlm.nih.gov/gene/?term=9547
Gene Name
CXCL14
Gene Alias
BMAC, BRAK, KEC, KS1, MIP-2g, MIP2G, NJAC, SCYB14
Protein Sub-location
Secreted Protein/Potential Cytokines
Previous slide
Next slide
Antigen Information
Cat No.
GM-Tg-hg-SE0135-Ag-1,GM-Tg-rg-SE0135-Ag-1,GM-Tg-mg-SE0135-Ag-1,GM-Tg-cynog-SE0135-Ag-1
Product Name
chemokine (C-X-C motif) ligand 14 (CXCL14) protein
Species
human, Cynomolgus/ Rhesus macaque, rat, mouse
Isotypes
Recombinant protein
Expression platform
Mammalian cell
Bioactivity validation
Affintiy&bioactivity validated by ELISA, cell culture validated
Tag
His
Product Description
Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-X-C motif) ligand 14 (CXCL14) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity
Purity: ≥95% (SDS-PAGE)
Application
Formulation
Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage
Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
Antibody Information
Catalog No.
GM-Tg-hg-SE0135-Ab-1, GM-Tg-hg-SE0135-Ab-2, GM-Tg-rg-SE0135-Ab-1, GM-Tg-rg-SE0135-Ab-2, GM-Tg-mg-SE0135-Ab-1, GM-Tg-mg-SE0135-Ab-2, GM-Tg-cynog-SE0135-Ab-1, GM-Tg-cynog-SE0135-Ab-2
Product Name
Anti-CXCL14 monoclonal antibody
Format
mab
Category of antibody
FACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)
Mouse
Species Reactivity
CH1+2+3 Isotype (Receptor identification)
IgG
Type of Light Chain (VD-LC)
N/A
Expression platform
Mammalian Expression
Bioactivity validation
Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Tag
Fc
Products description
Pre-made anti-CXCL14 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity
Purity: ≥95% (SDS-PAGE)
Application
Biological drug discovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation
Lyophilized from sterile PBS, PH 7.4
Storage
Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list
Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.
GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.
Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.
