Author Archives: shanzhu

DNA Stats returns the number of occurrences of each residue in the sequence you enter | GueeMedi

DNA Stats returns the number of occurrences of each residue in the sequence you enter DNA Stats returns the number of occurrences of each residue in the sequence you enter. Percentage totals are also given for each residue, and for certain groups of residues, allowing you to quickly compare the results obtained for different sequences. […]

Restriction Digest cleaves a DNA sequence in a virtual restriction digest, with one, two, or three restriction enzymes | GsteMedi

Restriction Digest cleaves a DNA sequence in a virtual restriction digest, with one, two, or three restriction enzymes Restriction Digest cleaves a DNA sequence in a virtual restriction digest, with one, two, or three restriction enzymes. The resulting fragments are sorted by size, and they are given a title specifying their length, their position in […]

Protein Stats returns the number of occurrences of each residue in the sequence you enter | GeseMedi

Protein Stats returns the number of occurrences of each residue in the sequence you enter Protein Stats returns the number of occurrences of each residue in the sequence you enter. Percentage totals are also given for each residue, and for certain groups of residues, allowing you to quickly compare the results obtained for different sequences. […]

DNA Molecular Weight accepts one or more DNA sequences and calculates molecular weight | Gd eMedi

DNA Molecular Weight accepts one or more DNA sequences and calculates molecular weight DNA Molecular Weight accepts one or more DNA sequences and calculates molecular weight. Sequences can be treated as double-stranded or single-stranded, and as linear or circular. Single-stranded sequences are assumed to have a 5′ phosphate. Use DNA Molecular Weight when calculating molecule […]

Atrial-Specific Gene Delivery Using an AAV Vector

Detail Introduction: Atrial diseases pose a major threaten to human health. Recently Ni L et al established an atrial-specific genetic manipulation system based on AAV (adeno-associated virus) vectors, which facilitates the pathogenesis study of atrial diseases and provides a powerful genetic tool for gene therapy study. The correlated findings were published in the journal of […]

Deamidation of Amino Acids on the Surface of AAV Capsids Leads to Charge Heterogeneity and Altered Vector Function

Detail Introduction: As an excellent gene therapy vector, AAV has been widely used for the treatment of many diseases, such as retinal dystrophy, cystic fibrosis, Duchenne Muscular Dystrophy, Hemophilia. However, post-translational modification of the AAV capsids and how they affect vector activity is poorly understood during the development of AAV vectors into pharmaceutical products. Recently, […]

Correction of half the cardiomyocytes fully rescue Friedreich Ataxia mitochondrial cardiomyopathy

Detail Introduction: Friedreich ataxia (FA) is a rare, neurodegenerative, autosomal recessive disease, characterized by spinocerebellar and sensory ataxia, including diabetes and cardiac hypertrophy, which is a major medical concern in FA, responsible for 59% of premature death of patients. FA is mainly caused by a (GAA)n expansion within the 1st intron of the frataxin gene […]