Pre-made Ligelizumab benchmark antibody ( Whole mAb, anti-IGHE/IgE therapeutic antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Ligelizumab biosimilar, Whole Mab: Anti-IGHE/IgE therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Ligelizumab (INN; development code QGE031) is a humanized IgG1 monoclonal antibody designed for the treatment of severe asthma and chronic spontaneous urticaria. It is an anti-IgE that binds to IGHE an acts as an immunomodulator.
| Products Name (INN Index) | Pre-Made Ligelizumab biosimilar, Whole Mab: Anti-IGHE/IgE therapeutic antibody |
|---|---|
| INN Name | Ligelizumab |
| Target | IGHE |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-III |
| Est. Status | Active |
| 100% SI Structure | 6uqr:AC |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2012 |
| Year Recommended | 2013 |
| Companies | Novartis,Tanox |
| Conditions Approved | NA |
| Conditions Active | Urticaria,Allergic asthma,Atopic dermatitis,Bullous pemphigoid |
| Conditions Discontinued | Hypersensitivity |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | IGHE |
| Package |
