Pre-made Tesidolumab benchmark antibody ( Whole mAb, anti-C5/CO5 therapeutic antibody, Anti-CPAMD4/ECLZB Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Tesidolumab biosimilar, Whole mAb, Anti-C5/CO5 Antibody: Anti-CPAMD4/ECLZB therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Tesidolumab, as known as LFG-316, is a human immunoglobulin G1 (IgG1) monoclonal antibody directed against the complement pathway protein C5, with complement pathway inhibitory activity and potential immunomodulating activity.
| Products Name (INN Index) | Pre-Made Tesidolumab biosimilar, Whole mAb, Anti-C5/CO5 Antibody: Anti-CPAMD4/ECLZB therapeutic antibody |
|---|---|
| INN Name | Tesidolumab |
| Target | C5 |
| Format | Whole mAb |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Lambda |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2014 |
| Year Recommended | 2015 |
| Companies | MorphoSys,Novartis |
| Conditions Approved | NA |
| Conditions Active | Paroxysmal nocturnal haemoglobinuria |
| Conditions Discontinued | Choroiditis,Dry age-related macular degeneration,Panuveitis,Thrombotic microangiopathy,Wet age-related macular degeneration |
| Development Tech | MorphoSys HuCAL Phage Display;XmAb Engineering Technology |
| Previous Name | NA |
| Gm Offical Target Name | C5 |
| Package |
