Pre-Made Bifarcept Biosimilar, Recombinant Protein targeting IFNA1: Recombinant therapeutic protein targeting IFL/IFN/IFN-ALPHA/IFN-alphaD/IFNA13/leIF D for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Bifarcept Biosimilar, Recombinant Protein targeting IFNA1: Recombinant therapeutic protein targeting IFL/IFN/IFN-ALPHA/IFN-alphaD/IFNA13/leIF D is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Bifarcept is a natural human interferon alpha proteins used for the treatment of genital warts. Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins.
| Products Name (INN Index) | Pre-Made Bifarcept Biosimilar, Recombinant Protein targeting IFNA1: Recombinant therapeutic protein targeting IFL/IFN/IFN-ALPHA/IFN-alphaD/IFNA13/leIF D |
|---|---|
| INN Name | bifarcept |
| Target | IFNA1 |
| Format | Recombinant Protein |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IFNAR2 (interferon type I receptor subunit 2) |
| VD LC | IFNAR2 (interferon type I receptor subunit 2) |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | NA |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | IFNA1 |
| Package |
