Norway rat Otub1 AAV plasmid
Cat:pGMAAV000273
Availability:3-7 business days
Description
Catalog ID
pGMAAV000273
Gene Name
Otub1
Product Name
Norway rat Otub1 AAV plasmid
Accession Number
NM_001106332.1
Gene ID
293705
Species
Norway rat
Product Type
AAV plasmid
Insert Length
816
Gene Alias
Predicted to enable ubiquitin binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein-specific protease activity. Involved in cellular response to interleukin-1. Located in cytoplasm and nucleus. Orthologous to human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
GFP
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Maker
Regulation
overexpression
