Norway rat Cav3 AAV plasmid
Cat:pGMAAV000277
Availability:3-7 business days
Description
Catalog ID
pGMAAV000277
Gene Name
Cav3
Product Name
Norway rat Cav3 AAV plasmid
Accession Number
NM_019155.2
Gene ID
29161
Species
Norway rat
Product Type
AAV plasmid
Insert Length
456
Gene Alias
Enables several functions, including nitric-oxide synthase binding activity; potassium channel inhibitor activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of cellular component organization; and response to ischemia. Located in several cellular components, including T-tubule; cell surface; and neuromuscular junction. Part of protein-containing complex. Colocalizes with several cellular components, including Z disc; intercalated disc; and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); isolated elevated serum creatine phosphokinase levels; and muscle tissue disease (multiple). Orthologous to human CAV3 (caveolin 3). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
ZsGreen
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq, Jul 2008]
Maker
Regulation
overexpression
