Cat:pGMAD000522
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMAD000522
Gene Name
Trem1
Product Name
Accession Number
NM_021406
Gene ID
58217
Species
house mouse
Product Type
Adenovirus plasmid
Insert Length
693
Gene Alias
Predicted to enable scaffold protein binding activity. Acts upstream of or within neutrophil chemotaxis; neutrophil extravasation; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in bladder and renal vasculature. Human ortholog(s) of this gene implicated in bacterial pneumonia; bacterial sepsis; malaria; and myocardial infarction. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
Null
Fusion Tag
Null
Promoter
CMV
Resistance
Amplicin
gene description
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Maker
Null
Regulation
overexpression
