Cat:pGMAD000523
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMAD000523
Gene Name
Bag3
Product Name
Accession Number
NM_001011936.1
Gene ID
293524
Species
Norway rat
Product Type
Adenovirus plasmid
Insert Length
1725
Gene Alias
Predicted to enable adenyl-nucleotide exchange factor activity and chaperone binding activity. Involved in several processes, including central nervous system development; chaperone-mediated autophagy; and negative regulation of protein targeting to mitochondrion. Located in neuron projection and stress fiber. Used to study glioblastoma. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
Null
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Maker
Null
Regulation
overexpression
