human SHC1 Lentivirus plasmid
Cat:pGMLV000477
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMLV000477
Gene Name
SHC1
Product Name
human SHC1 Lentivirus plasmid
Accession Number
NM_001130041.1
Gene ID
6464
Species
human
Product Type
Lentivirus plasmid
Insert Length
1422
Gene Alias
SHC;SHCA
Fluorescent Label
GFP+PURO
Fusion Tag
NULL
Promoter
CMV
Resistance
Amplicin
gene description
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Maker
GFP+PURO
Regulation
overexpression
