Pre-made Bavituximab benchmark antibody ( Whole mAb, anti-Phosphatidylserine therapeutic antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Bavituximab biosimilar, Whole Mab: Anti-Phosphatidylserine therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Bavituximab (PGN401) is a human-mouse chimeric monoclonal antibody against phosphatidylserine, which is a component of cell membranes that is exposed when a cell is transformed into solid tumor cancer cell or dies, and when cells are infected with hepatitis C.[3] The process of cell death is highly controlled and so there usually no immune response to phosphatidylserine but when bavituximab binds to it, the conjugate appears to stimulate an immune response in humans.
| Products Name (INN Index) | Pre-Made Bavituximab biosimilar, Whole Mab: Anti-Phosphatidylserine therapeutic antibody |
|---|---|
| INN Name | Bavituximab |
| Target | Phosphatidylserine |
| Format | Whole mAb |
| Derivation | Chimeric (Mouse/Human) |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-III |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2006 |
| Year Recommended | 2007 |
| Conditions Approved | NA |
| Conditions Active | Non-small cell lung cancer,Glioblastoma,Liver cancer,Solid tumours |
| Conditions Discontinued | Breast cancer,Malignant melanoma,Pancreatic cancer,Brain cancer,Hepatitis C,HIV infections,Rectal cancer,Viral haemorrhagic fevers,Influenza virus infections,Prostate cancer |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | Phosphatidylserine |
| Package |
