Pre-made Cadonilimab benchmark antibody ( Bispecific Mixed mAb and scFv, anti-PDCD1/PD-1;CTLA4/CTLA-4 therapeutic antibody, Anti-CD279/PD1/SLEB2/hPD-1/hPD-l/hSLE1;CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-made Cadonilimab benchmark antibody (Bispecific Mixed mAb and scFv, anti-PDCD1/PD-1;CTLA4/CTLA-4 therapeutic antibody, Anti-CD279/PD1/SLEB2/hPD-1/hPD-l/hSLE1;CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 Antibody) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Cadonilimab (AK104) is a novel, potential next-generation,first-in-classbi-specificPD-1/CTLA-4immuno-oncology backbone drug independently developed by the Company, and its major indications include liver cancer, cervical cancer, lung cancer, gastric cancer, esophageal squamous cell cancer and nasopharyngeal carcinoma.
| Products Name (INN Index) | Pre-Made Cadonilimab biosimilar, Bispecific Mixed mAb and scFv, Anti-PDCD1/PD-1;CTLA4/CTLA-4 antibody: Anti-CD279/PD1/SLEB2/hPD-1/hPD-l/hSLE1;CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibo |
|---|---|
| INN Name | Cadonilimab |
| Target | PDCD1,CTLA4 |
| Format | Bispecific Mixed mAb and scFv |
| Derivation | Bispecific antibody |
| Species Reactivity | Human |
| CH1 Isotype | IgG1;na |
| VD LC | Kappa,Lambda |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None;None |
| 99% SI Structure | None;None |
| 95-98% SI Structure | None;None |
| Year Proposed | 2020 |
| Year Recommended | NA |
| Companies | Akeso Biopharma |
| Conditions Approved | NA |
| Conditions Active | Non-small cell lung cancer,Solid tumours,Peripheral T/NK cell lymphoma,Hepatocellular carcinoma,Gastic adenocarcinoma,Nasopharyngeal carcinoma |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | PDCD1/PD-1,CTLA4/CTLA-4 |
| Package |
