Pre-made Eculizumab benchmark antibody ( Whole mAb, anti-C5/CO5 therapeutic antibody, Anti-CPAMD4/ECLZB Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-164

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SKU GMP-Bios-ab-164 Category Tag

Product Details

Pre-Made Eculizumab biosimilar, Whole mAb, Anti-C5/CO5 Antibody: Anti-CPAMD4/ECLZB therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Eculizumab, sold under the brand name Soliris among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and neuromyelitis optica. In people with PNH, it reduces both the destruction of red blood cells and need for blood transfusion, but does not appear to affect the risk of death. Eculizumab was the first drug approved for each of its uses, and its approval was granted based on small trials.[2][3][4][5] It is given in a clinic by intravenous (IV) infusion.

Products Name (INN Index)

Pre-Made Eculizumab biosimilar, Whole mAb, Anti-C5/CO5 Antibody: Anti-CPAMD4/ECLZB therapeutic antibody

INN Name

Eculizumab

Target

C5

Format

Whole mAb

Derivation

Humanized

Species Reactivity

Human

CH1 Isotype

IgG2

VD LC

Kappa

Highest_Clin_Trial (Jan '20)

Approved

Est. Status

Active

100% SI Structure

5i5k:HL:XY

99% SI Structure

None

95-98% SI Structure

None

Year Proposed

2002

Companies

Alexion Pharmaceuticals,Brigham and Womens Hospital,Chiba University,Handok Inc

Conditions Approved

Neuromyelitis optica,Haemolytic uraemic syndrome,Myasthenia gravis,Paroxysmal nocturnal haemoglobinuria

Conditions Active

Delayed graft function,Guillain-Barre syndrome,Renal transplant rejection,COVID-19

Conditions Discontinued

Antiphospholipid syndrome,Heart transplant rejection,Adult respiratory distress syndrome,Age-related macular degeneration,Allergic asthma,Autoimmune haemolytic anaemia,Bullous pemphigoid,Dermatomyosi

Development Tech

GS Gene Expression System

Previous Name

NA

Gm Offical Target Name

C5

Package

, ,

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