Pre-made Ranibizumab benchmark antibody ( Fab, anti-VEGFA therapeutic antibody, Anti-VPF/VEGF/MVCD1 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Ranibizumab biosimilar, Fab, Anti-VEGFA Antibody: Anti-VPF/VEGF/MVCD1 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Ranibizumab (trade name Lucentis among others) is a monoclonal antibody fragment (Fab) created from the same parent mouse antibody as bevacizumab. It is an anti-angiogenic that has been approved to treat the “wet” type of age-related macular degeneration (AMD, also ARMD), diabetic retinopathy, and macular edema due to branch retinal vein occlusion or central retinal vein occlusion.
| Products Name (INN Index) | Pre-Made Ranibizumab biosimilar, Fab, Anti-VEGFA Antibody: Anti-VPF/VEGF/MVCD1 therapeutic antibody |
|---|---|
| INN Name | Ranibizumab |
| Target | VEGFA |
| Format | Fab |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Approved |
| Est. Status | Active |
| 100% SI Structure | 1cz8:HL:YX |
| 99% SI Structure | None |
| 95-98% SI Structure | 1bj1:HL:KJ/6bft:HL:AB |
| Year Proposed | 2004 |
| Year Recommended | 2004 |
| Companies | Genentech,Manhattan Eye Ear & Throat Hospital,Novartis Ophthalmics,University of Bonn |
| Conditions Approved | Choroidal neovascularisation,Degenerative myopia,Diabetic macular oedema,Retinal oedema,Wet age-related macular degeneration,Diabetic retinopathy |
| Conditions Active | Retinopathy of prematurity,Polypoidal choroidal vasculopathy |
| Conditions Discontinued | Retinal telangiectasis |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | VEGFA |
| Package |
