Pre-made Tralokinumab benchmark antibody ( Whole mAb, anti-IL13 therapeutic antibody, Anti-IL-13/P600 Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-592

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SKU GMP-Bios-ab-592 Category Tag

Product Details

Pre-Made Tralokinumab biosimilar, Whole mAb, Anti-IL13 Antibody: Anti-IL-13/P600 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Tralokinumab is a human monoclonal antibody which targets the cytokine interleukin 13,[1] and is designed for the treatment of asthma and other inflammatory diseases. Tralokinumab was discovered by Cambridge Antibody Technology scientists, using Ribosome Display, as CAT-354 and taken through pre-clinical and early clinical development. After 2007 it has been developed by MedImmune, a member of the AstraZeneca group, where it is currently in Ph3 testing for asthma and Ph2b testing for atopic dermatitis. This makes it one of the few fully internally discovered and developed drug candidates in AstraZeneca’s late stage development pipeline.

Products Name (INN Index)

Pre-Made Tralokinumab biosimilar, Whole mAb, Anti-IL13 Antibody: Anti-IL-13/P600 therapeutic antibody

INN Name

Tralokinumab

Target

IL13

Format

Whole mAb

Derivation

Human

Species Reactivity

Human

CH1 Isotype

IgG4

VD LC

Lambda

Highest_Clin_Trial (Jan '20)

Approved

Est. Status

Active

100% SI Structure

5l6y:HL

99% SI Structure

None

95-98% SI Structure

None

Year Proposed

2009

Companies

Cambridge Antibody Technology,Icahn School of Medicine at Mount Sinai,LEO Pharma,MedImmune

Conditions Approved

NA

Conditions Active

Atopic dermatitis,Alopecia areata

Conditions Discontinued

Asthma,Chronic obstructive pulmonary disease,Idiopathic pulmonary fibrosis,Ulcerative colitis

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

IL13

Package

, ,

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