Pre-made Ustekinumab benchmark antibody ( Whole mAb, anti-IL12B therapeutic antibody, Anti-CLMF/CLMF2/IL-12B/IMD28/IMD29/NKSF/NKSF2 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Ustekinumab biosimilar, Whole mAb, Anti-IL12B Antibody: Anti-CLMF/CLMF2/IL-12B/IMD28/IMD29/NKSF/NKSF2 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Ustekinumab, sold under the brand name Stelara?, is a monoclonal antibody medication developed by Janssen Pharmaceuticals, for the treatment of Crohn’s disease, Ulcerative Colitis, Plaque Psoriasis and Psoriatic Arthritis, targeting both IL-12 and IL-23.
| Products Name (INN Index) | Pre-Made Ustekinumab biosimilar, Whole mAb, Anti-IL12B Antibody: Anti-CLMF/CLMF2/IL-12B/IMD28/IMD29/NKSF/NKSF2 therapeutic antibody |
|---|---|
| INN Name | Ustekinumab |
| Target | IL12B |
| Format | Whole mAb |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Approved |
| Est. Status | Active |
| 100% SI Structure | 3hmw:HL/3hmx:HL |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2008 |
| Year Recommended | 2009 |
| Companies | Centocor Inc,Janssen Biotech,Medarex |
| Conditions Approved | Crohn's disease,Plaque psoriasis,Psoriatic arthritis |
| Conditions Active | Ulcerative colitis,Spondylarthritis,Systemic lupus erythematosus,Atopic dermatitis |
| Conditions Discontinued | Multiple sclerosis,Palmoplantar pustulosis,Primary biliary cirrhosis,Rheumatoid arthritis,Sarcoidosis |
| Development Tech | Medarex UltiMAb Mouse |
| Previous Name | NA |
| Gm Offical Target Name | IL12B |
| Package |
