Pre-made Vedolizumab benchmark antibody ( Whole mAb, anti-ITGA4;ITGB7 therapeutic antibody, Anti-CD49D/IA4 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-made Vedolizumab benchmark antibody (Whole mAb, anti-ITGA4;ITGB7 therapeutic antibody, Anti-CD49D/IA4 Antibody) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Vedolizumab, sold under the brand name Entyvio, is a monoclonal antibody medication developed by Millennium Pharmaceuticals, Inc (currently named Takeda Oncology, a subsidiary of Takeda Pharmaceuticals) for the treatment of ulcerative colitis and Crohn’s disease. It binds to integrin ¦Á4¦Â7 (LPAM-1, lymphocyte Peyer’s patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7). Blocking the ¦Á4¦Â7 integrin results in gut-selective anti-inflammatory activity. It is marketed under the trade name Entyvio.
| Products Name (INN Index) | Pre-Made Vedolizumab biosimilar, Whole mAb, Anti-ITGA4;ITGB7 Antibody: Anti-CD49D/IA4 therapeutic antibody |
|---|---|
| INN Name | Vedolizumab |
| Target | ITGA4_ITGB7 |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Approved |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2008 |
| Year Recommended | 2009 |
| Companies | Medical College of Wisconsin,Millennium Pharmaceuticals,Takeda,Takeda Oncology |
| Conditions Approved | Crohn's disease,Ulcerative colitis |
| Conditions Active | Graft-versus-host disease,Coeliac disease |
| Conditions Discontinued | Malignant melanoma |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | ITGA4_ITGB7 |
| Package |
