Pre-made Vibecotamab benchmark antibody ( Bispecific Mixed mAb and scFv, anti-IL3RA;CD3E therapeutic antibody, Anti-CD123/IL3RX/IL3RY/IL3RAY/hIL-3Ra;T3E/TCRE/IMD18 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Vibecotamab biosimilar, Bispecific Mixed mAb and scFv, Anti-IL3RA;CD3E Antibody: Anti-CD123/IL3RX/IL3RY/IL3RAY/hIL-3Ra;T3E/TCRE/IMD18 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Vibecotamab (XmAb?14045) is a tumor-targeted antibody that contains both a CD123 binding domain and a cytotoxic T-cell binding domain (CD3) in a Phase 1 clinical trial for the treatment of acute myeloid leukemia (AML) and other CD123-expressing hematologic malignancies.
| Products Name (INN Index) | Pre-Made Vibecotamab biosimilar, Bispecific Mixed mAb and scFv, Anti-IL3RA;CD3E Antibody: Anti-CD123/IL3RX/IL3RY/IL3RAY/hIL-3Ra;T3E/TCRE/IMD18 therapeutic antibody |
|---|---|
| INN Name | Vibecotamab |
| Target | IL3RA,CD3E |
| Format | Bispecific Mixed mAb and scFv |
| Derivation | Bispecific antibody |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa,Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-I |
| Est. Status | Active |
| 100% SI Structure | None;None |
| 99% SI Structure | None;None |
| 95-98% SI Structure | None;None |
| Year Proposed | 2018 |
| Year Recommended | 2019 |
| Companies | Xencor |
| Conditions Approved | NA |
| Conditions Active | Haematological malignancies |
| Conditions Discontinued | NA |
| Development Tech | XmAb? bispecific platformna (For heterodimer, E357Q/S364K-L368D/K370S; For purification with PI, N208D in CH1, Q295E in CH2, and N384D, Q418E, and N421D in CH3.) |
| Previous Name | NA |
| Gm Offical Target Name | IL3RA,CD3E |
| Package |
