Pre-Made Batiraxcept Biosimilar, Fusion Protein targeting GAS6 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AXLLG/AXSF for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Batiraxcept Biosimilar, Fusion Protein targeting GAS6 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AXLLG/AXSF is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Batiraxcept is a soluble fusion protein comprised of the extracellular domain of the receptor tyrosine kinase (RTK) AXL (UFO) fused to a human immunoglobulin G1 (IgG1) Fc domain, with potential antineoplastic activity. Batiraxcept selectively binds to growth arrest-specific protein 6 (GAS6), the endogenous ligand for AXL. This may inhibit GAS6/AXL-mediated signaling, which plays a key role in tumor cell proliferation, survival, invasion and metastasis, as well as immune evasion and resistance to other anticancer agents.
| Products Name (INN Index) | Pre-Made Batiraxcept Biosimilar, Fusion Protein targeting GAS6 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AXLLG/AXSF |
|---|---|
| INN Name | batiraxcept |
| Target | GAS6 |
| Format | Fusion Protein |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | Fusion – [AXL (AXL receptor tyrosine kinase, ARK, JTK11, Tyro7, UFO)]2 – IGHG1 Fc (Fragment constant) |
| VD LC | Fusion – [AXL (AXL receptor tyrosine kinase, ARK, JTK11, Tyro7, UFO)]2 – IGHG1 Fc (Fragment constant) |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Aravive?Biologics, Inc. (Houston TX USA) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | GAS6 |
| Package |
