Pre-Made Ontorpacept Biosimilar, Fusion Protein targeting CD47 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting IAP/MER6/OA3 for drug discovery and mechanism of action (MOA) research
* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry
Product Details
Pre-Made Ontorpacept Biosimilar, Fusion Protein targeting CD47 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting IAP/MER6/OA3 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Ontorpacept is a fusion protein consisting of Signal regulatory protein ¦Á (SIRP¦Á) fused to the human IgG1 Fc region, that binds to CD47 and blocks inhibitory signaling to macrophages, resulting in increased phagocytosis of tumor cells
| Products Name (INN Index) | Pre-Made Ontorpacept Biosimilar, Fusion Protein targeting CD47 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting IAP/MER6/OA3 |
|---|---|
| INN Name | ontorpacept |
| Target | CD47 |
| Format | Fusion Protein |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | Fusion – SIRPA (signal regulatory protein alpha, SHPS1, SIRP, SIRPalpha) – IGHG1 (Fc (Fragment constant) |
| VD LC | Fusion – SIRPA (signal regulatory protein alpha, SHPS1, SIRP, SIRPalpha) – IGHG1 (Fc (Fragment constant) |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Trillium Therapeutics?Inc. (Mississauga Canada) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | CD47 |
| Package |
