Pre-Made Recifercept biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting FGF for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Recifercept biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting FGF is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Achondroplasia is a rare genetic disorder caused by mutations in the Fibroblast Growth Factor receptor 3 (FGFR3). These mutations lead to aberrant increase of inhibitory signaling in proliferating chondrocytes at the growth plate. Recifercept is a soluble recombinant human fibroblast growth factor receptor 3 (FGFR3). Recifercept is a potential treatment for this disease using a decoy approach to sequester FGFR3 ligands subsequently normalizing activation of the mutated FGFR3 receptor. Recifercept binds to FGF isoforms in vitro and in cellular model systems and reduces FGFR3 signaling.
| Products Name (INN Index) | Pre-Made Recifercept biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting FGF |
|---|---|
| INN Name | recifercept |
| Target | FGF |
| Format | Recombinant Protein |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | FGFR3 (fibroblast growth factor receptor 3, ACH, achondroplasia, thanatophoric dwarfism, CEK2, CD333) Soluble |
| VD LC | FGFR3 (fibroblast growth factor receptor 3, ACH, achondroplasia, thanatophoric dwarfism, CEK2, CD333) Soluble |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Pfizer (New York NY USA) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | FGF |
| Package |
