Pre-Made Retlirafusp Alfa Biosimilar, Fusion Protein targeting CD274/PD-L1 fused with human TGFBR2 (transforming growth factor beta receptor 2) extracellular fragment (20-136) via a peptidyl linker: Recombinant therapeutic protein targeting B7-H/B7H1/PDCD1L1/PDCD1LG1 for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-INN-972

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SKU GMP-Bios-INN-972 Category Tag

Product Details

Pre-Made Retlirafusp Alfa Biosimilar, Fusion Protein targeting CD274/PD-L1 fused with human TGFBR2 (transforming growth factor beta receptor 2) extracellular fragment (20-136) via a peptidyl linker: Recombinant therapeutic protein targeting B7-H/B7H1/PDCD1L1/PDCD1LG1 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Retlirafusp alfa is a novel bifunctional fusion protein composed of a mAb against PD-L1 fused with the extracellular domain of TGF-b receptor II. Retlirafusp alfa target programmed cell death ligand-1 (PDL-1) and transforming growth factor-¦Â (TGF-¦Â) and exhibits antitumor activity.

Products Name (INN Index)

Pre-Made Retlirafusp Alfa Biosimilar, Fusion Protein targeting CD274/PD-L1 fused with human TGFBR2 (transforming growth factor beta receptor 2) extracellular fragment (20-136) via a peptidyl linker:

INN Name

retlirafusp alfa

Target

CD274

Format

Fusion Protein

Derivation

Human

Species Reactivity

Human

CH1 Isotype

IgG4 – kappa

VD LC

IgG4 – kappa

Highest_Clin_Trial (Jan '20)

NA

Est. Status

NA

100% SI Structure

NA

99% SI Structure

NA

95-98% SI Structure

NA

Year Proposed

NA

Companies

Jiangsu?Hengrui Medicine?Co.,?Ltd. (Lianyungang Jiangsu China)

Conditions Approved

NA

Conditions Active

NA

Conditions Discontinued

NA

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

CD274

Package

, ,

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