Pre-Made Romiplostim Biosimilar, Fusion Protein targeting MPL fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting C-MPL/CD110/MPLV/THCYT2/THPOR/TPOR for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Romiplostim Biosimilar, Fusion Protein targeting MPL fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting C-MPL/CD110/MPLV/THCYT2/THPOR/TPOR is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Romiplostim is a fusion protein of thrombopoietin (TPO) peptide analog with Fc-peptide (peptibody) to increase platelet production through activation of the thrombopoietin receptor. It is used to treat thrombocytopenia associated with chronic immune thrombocytopenia (ITP).
| Products Name (INN Index) | Pre-Made Romiplostim Biosimilar, Fusion Protein targeting MPL fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting C-MPL/CD110/MPLV/THCYT2/THPOR/TPOR |
|---|---|
| INN Name | romiplostim |
| Target | MPL |
| Format | Fusion Protein |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | Fusion – IGHG1 Fc (Fragment constant) – [peptide 14-mer – peptide 14-mer]2 |
| VD LC | Fusion – IGHG1 Fc (Fragment constant) – [peptide 14-mer – peptide 14-mer]2 |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Amgen (Thousand Oaks CA USA) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | Peptide phage display library |
| Previous Name | NA |
| Gm Offical Target Name | MPL |
| Package |
