human, Cynomolgus/ Rhesus macaque, rat, mouse interferon, lambda 3 (IFNL3) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.

Cat:GM-Tg-hg-T55242-Ag-1
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Description

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse interferon, lambda 3 (IFNL3) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. Interferon lambda 3 (gene symbol: IFNL3) encodes the IFNL3 protein. IFNL3 was formerly named IL28B, but the Human Genome Organization Gene Nomenclature Committee renamed this gene in 2013 while assigning a name to the then newly discovered IFNL4 gene. Together with IFNL1 (formerly IL29) and IFNL2 (formerly IL28A), these genes lie in a cluster on chromosomal region 19q13. IFNL3 shares ~96% amino-acid identity with IFNL2, ~80% identity with IFNL1 and ~30% identity with IFNL4. Interferon lambda genes encode cytokines classified as type III interferons, which are distantly related to type I interferons and the IL-10 family. Type III interferons are induced by viral infection and interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interferon lambda receptor 1 (IFNLR1) to signal via the JAK-STAT anti-viral pathway.

Target Information

Target Name

IFNL3

Full name

interferon, lambda 3

Gene ID

https://www.ncbi.nlm.nih.gov/gene/?term=282617

Gene Name

IFNL3

Gene Alias

IFN-lambda-3, IFN-lambda-4, IL-28B, IL-28C, IL28B, IL28C

Protein Sub-location

Secreted Protein/Potential Cytokines
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Antigen Information

Cat No.

GM-Tg-hg-T55242-Ag-1,GM-Tg-rg-T55242-Ag-1,GM-Tg-mg-T55242-Ag-1,GM-Tg-cynog-T55242-Ag-1

Product Name

interferon, lambda 3 (IFNL3) protein

Species

human, Cynomolgus/ Rhesus macaque, rat, mouse

Isotypes

Recombinant protein

Expression platform

Mammalian cell

Bioactivity validation

Affintiy&bioactivity validated by ELISA, cell culture validated

Tag

His

Product Description

Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse interferon, lambda 3 (IFNL3) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.

Purity

Purity: ≥95% (SDS-PAGE)

Application

Formulation

Supplied as a 0.2 μM filtered solution of PBS, PH7.4.

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.

GM-Tg-hg-T55242-Ab-1, GM-Tg-hg-T55242-Ab-2, GM-Tg-rg-T55242-Ab-1, GM-Tg-rg-T55242-Ab-2, GM-Tg-mg-T55242-Ab-1, GM-Tg-mg-T55242-Ab-2, GM-Tg-cynog-T55242-Ab-1, GM-Tg-cynog-T55242-Ab-2

Product Name

Anti-IFNL3 monoclonal antibody

Format

mab

Category of antibody

FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody

Derivation (species)

Mouse

Species Reactivity

CH1+2+3 Isotype (Receptor identification)

IgG

Type of Light Chain (VD-LC)

N/A

Expression platform

Mammalian Expression

Bioactivity validation

Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Tag

Fc

Products description

Pre-made anti-IFNL3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)

Purity

Purity: ≥95% (SDS-PAGE)

Application

Biological drug discovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Formulation

Lyophilized from sterile PBS, PH 7.4

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list

Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.

GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.

Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.