Pre-made anti-HLA-DRB3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research.

Cat:GM-Tg-hg-TA142-Ab
* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry

$3,090.00

SKU GM-Tg-hg-TA142-Ab Category

Description

Pre-made anti-HLA-DRB3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-HLA-DRB3 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. The target: HLA-DRB3, gene name: HLA-DRB3, also named as HLA-DPB1, HLA-DR1B, HLA-DR3B. HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020].

Antigen Information

Catalog No.

GM-Tg-hg-TA142-Ab-1,GM-Tg-hg-TA142-Ab-2

Product Name

Anti-HLA-DRB3 monoclonal antibody

Format

mab

Target Name

HLA-DRB3

Gene ID

HLA-DRB3

Gene Name

HLA-DRB3

Gene Alias

HLA-DPB1, HLA-DR1B, HLA-DR3B

Protein Sub-location

Introcelluar Protein

Category of antibody

Therapeutics Target antibody

Derivation (species)

Mouse

Species Reactivity

Human(H)

CH1+2+3 Isotype (Receptor identification)

IgG

Type of Light Chain (VD-LC)

N/A

Expression platform

Mammalian Expression

Bioactivity validation

Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.

Tag

Fc

Products description

Pre-made anti-HLA-DRB3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)

Purity

Purity: ≥95% (SDS-PAGE)

Application

Biological drug discovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Formulation

Lyophilized from sterile PBS, PH 7.4

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.