Recombinant 2019-nCoV(SARS-CoV-2) Spike Protein RBD (E484Q+L452R) mutant (double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India))

Recombinant 2019-nCoV(SARS-CoV-2) Spike Protein RBD (E484Q+L452R) mutant (double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India))
The world is in midst of the COVID-19 pandemic. Recently A new “double mutant” variant of the coronavirus has been detected from samples collected in India. The two mutations (E484Q and L452R mutations) come together in the same virus, may be more infectious or less affected by vaccines.1

Mutations of Spike protein in SARS-COV-2 (2019nCOV) double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India)
Two of the spike mutations are at key residues in the RBD (E484Q and L452R), two are in the N-terminal domain (T95I and E154K).2

Spike Mutation in SARS-COV-2 (2019nCOV) double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India) Spike-S1 Subunit
N Terminal T95I
E154K Important residues mutation
Spike-RBD L452R Important residues mutation
E484Q Important residues mutation
Spike-S1 Subunit D614G A popular mutation in different new SARS-CoV-2 lineage
Spike-S2 Subunit P681R
Recombinant 2019-nCoV(SARS-CoV-2) Spike Protein RBD (E484Q+L452R) mutant (double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India))

The world is in midst of the COVID-19 pandemic. Recently A new “double mutant” variant of the coronavirus has been detected from samples collected in India. The two mutations (E484Q and L452R mutations) come together in the same virus, may be more infectious or less affected by vaccines.1

Mutations of Spike protein in SARS-COV-2 (2019nCOV) double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India)
Two of the spike mutations are at key residues in the RBD (E484Q and L452R), two are in the N-terminal domain (T95I and E154K).2

Spike Mutation in SARS-COV-2 (2019nCOV) double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India) Spike-S1 Subunit
N Terminal T95I
E154K Important residues mutation
Spike-RBD L452R Important residues mutation
E484Q Important residues mutation
Spike-S1 Subunit D614G A popular mutation in different new SARS-CoV-2 lineage
Spike-S2 Subunit P681R