rat Sirt3 AAV plasmid
Cat:pGMAAV000011
Availability:3-7 business days
Description
Catalog ID
pGMAAV000011
Gene Name
Sirt3
Product Name
rat Sirt3 AAV plasmid
Accession Number
NM_001106313.2
Gene ID
293615
Species
rat
Product Type
AAV plasmid
Insert Length
774
Gene Alias
Enables enzyme binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; and positive regulation of insulin secretion. Located in mitochondrion. Used to study non-alcoholic fatty liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
GFP
Fusion Tag
FLAG
Promoter
CMV
Resistance
Amplicin
gene description
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
Maker
Regulation
overexpression
