Norway rat Tnfrsf10b AAV plasmid
Cat:pGMAAV000358
Availability:3-7 business days
Description
Catalog ID
pGMAAV000358
Gene Name
Tnfrsf10b
Product Name
Norway rat Tnfrsf10b AAV plasmid
Accession Number
NM_001108873
Gene ID
364420
Species
Norway rat
Product Type
AAV plasmid
Insert Length
804
Gene Alias
Predicted to enable identical protein binding activity and protease binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors; male gonad development; and response to organic cyclic compound. Located in membrane. Biomarker of colon cancer and osteoarthritis. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to human TNFRSF10A (TNF receptor superfamily member 10a). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
GFP
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Maker
Regulation
overexpression
