Cat:pGMAD000312
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMAD000312
Gene Name
Calr
Product Name
Accession Number
NM_022399.2
Gene ID
64202
Species
rat
Product Type
Adenovirus plasmid
Insert Length
1251
Gene Alias
Enables several functions, including hormone binding activity; metal ion binding activity; and peptide binding activity. Involved in several processes, including cellular response to lithium ion; response to estradiol; and response to testosterone. Located in several cellular components, including acrosomal vesicle; endoplasmic reticulum; and perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of vitamin B12 deficiency. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; pancreatic ductal adenocarcinoma; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
GFP
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]
Maker
GFP
Regulation
overexpression
