Cat:pGMAD000421
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMAD000421
Gene Name
Atg5
Product Name
Accession Number
NM_001014250
Gene ID
365601
Species
Norway rat
Product Type
Adenovirus plasmid
Insert Length
654
Gene Alias
Involved in several processes, including chaperone-mediated autophagy; response to fluoride; and response to iron(II) ion. Located in axon. Part of protein-containing complex. Biomarker of ischemia. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
GFP
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Maker
GFP
Regulation
overexpression
