Human ACE2 overexpression stable HEK293T cell lines

GeneMedi’s human ACE2 overexpression stable HEK293T cell lines (Cat.GM-SC-293T-hACE2-01)is a efforter cell in SARS-CoV-2(2019nCoV) Pseudotyped Virus Based Neutralization Assay and SARS-CoV-2 Pseudovirus (PSV) Based Cell Entry.
The SARS-CoV-2 pseudovirus particles encode firefly luciferase and RFP in their lentiviral vector genome. The firefly luciferase and RFP gene will be strongly expressed after the SARS-CoV-2 pseudovirus entry into ACE2-expressing cells. GeneMedi’s human ACE2 overexpression stable HEK293T cell lines (Cat.GM-SC-293T-hACE2-01)is is normally used as effector cell.
In the Pseudovirus Based Neutralization Assay (PBNA), the inhibition of viral entry into cells by neutralizing antibodies is correlated to the decreased levels of firefly luciferase signals in hACE2 expressing effector cell(Cat.GM-SC-293T-hACE2-01).SARS-CoV-2(2019nCoV) Pseudotyped Virus Based Neutralization Assay (PBNA)Service with GeneMedi’s hACE2-expressing effector cell is applied for evaluating:
1) Neutralizing antibodies
2) Peptides blockers(peptide inhibitors)
3) Types of Vaccines3(by testing immunized serum from mouse, NHP etc.)
4) Compounds targeting Spike induced cell-fusion.