Pre-made Alemtuzumab benchmark antibody ( Whole mAb, anti-CD52 therapeutic antibody, Anti-HE5/CDW52/EDDM5 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Alemtuzumab biosimilar, Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Alemtuzumab, sold under the brand names Campath and Lemtrada among others, is a medication used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis. In CLL, it has been used as both a first line and second line treatment. In MS it is generally only recommended if other treatments have not worked. It is given by injection into a vein.
| Products Name (INN Index) | Pre-Made Alemtuzumab biosimilar, Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody |
|---|---|
| INN Name | Alemtuzumab |
| Target | CD52 |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Approved |
| Est. Status | Active |
| 100% SI Structure | 1bey:HL/1ce1:HL |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2000 |
| Year Recommended | 2001 |
| Companies | Bayer HealthCare Pharmaceuticals Inc.,Dana-Farber Cancer Institute,German CLL Study Group,Ohio State University Comprehensive Cancer Center,Sanofi,Sanofi Oncology,University of Cologne,University of |
| Conditions Approved | Chronic lymphocytic leukaemia,Multiple sclerosis |
| Conditions Active | Lymphoma,T-cell prolymphocytic leukaemia |
| Conditions Discontinued | Rheumatoid arthritis,Diffuse large B cell lymphoma,Graft-versus-host disease,Sezary syndrome,T-cell lymphoma |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | CD52 |
| Package |
