Pre-made Bermekimab benchmark antibody ( Whole mAb, anti-IL1A therapeutic antibody, Anti-IL1/IL-1A/IL1F1/IL1-ALPHA/IL-1 alpha Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Bermekimab biosimilar, Whole mAb, Anti-IL1A Antibody: Anti-IL1/IL-1A/IL1F1/IL1-ALPHA/IL-1 alpha therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Bermekimab[1] (MABp1, trade name Xilonix) is a human monoclonal antibody of IgG1k isotype targeting Interleukin 1 alpha (IL1A). As of March 2017, bermekimab is in phase III clinical trials as an immunotherapy for colorectal cancer and as of September 2018 in phase II clinical trials for the treatment of atopic dermatitis.
| Products Name (INN Index) | Pre-Made Bermekimab biosimilar, Whole mAb, Anti-IL1A Antibody: Anti-IL1/IL-1A/IL1F1/IL1-ALPHA/IL-1 alpha therapeutic antibody |
|---|---|
| INN Name | Bermekimab |
| Target | IL1A |
| Format | Whole mAb |
| Derivation | NA |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Preregistration |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2018 |
| Year Recommended | 2019 |
| Companies | XBiotech Inc. |
| Conditions Approved | NA |
| Conditions Active | Colorectal cancer,Cachexia,Atopic dermatitis,Acne vulgaris,Hidradenitis suppurativa,Non-small cell lung cancer,Plaque psoriasis,Systemic scleroderma,Type 2 diabetes mellitus,Vascular restenosis,Pancr |
| Conditions Discontinued | Haematological malignancies |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | IL1A |
| Package |
