Pre-made Daclizumab benchmark antibody ( Whole mAb, anti-IL2RA therapeutic antibody, Anti-CD25/IDDM10/IL2R/IMD41/TCGFR/p55 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Daclizumab biosimilar, Whole mAb, Anti-IL2RA Antibody: Anti-CD25/IDDM10/IL2R/IMD41/TCGFR/p55 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Daclizumab (trade name Zinbryta) is a therapeutic humanized monoclonal antibody which was used for the treatment of adults with relapsing forms of multiple sclerosis (MS). Daclizumab works by binding to CD25, the alpha subunit of the IL-2 receptor of T-cells.
| Products Name (INN Index) | Pre-Made Daclizumab biosimilar, Whole mAb, Anti-IL2RA Antibody: Anti-CD25/IDDM10/IL2R/IMD41/TCGFR/p55 therapeutic antibody |
|---|---|
| INN Name | Daclizumab |
| Target | IL2RA |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Approved |
| Est. Status | Active |
| 100% SI Structure | 3nfs:HL/3nfp:HL:AB |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 1994 |
| Year Recommended | 1998 |
| Companies | AbbVie,Biogen,Dana-Farber Cancer Institute,National Cancer Institute (USA),PDL BioPharma |
| Conditions Approved | Renal transplant rejection |
| Conditions Active | Multiple sclerosis |
| Conditions Discontinued | Asthma,Graft-versus-host disease,Haematological malignancies,Immune-mediated uveitis,Liver transplant rejection,Psoriasis,Tropical spastic paraparesis,Type 1 diabetes mellitus,Ulcerative colitis |
| Development Tech | GS Gene Expression System |
| Previous Name | NA |
| Gm Offical Target Name | IL2RA |
| Package |
