Pre-made Daratumumab benchmark antibody ( Whole mAb, anti-CD38 therapeutic antibody, Anti-ADPRC1/ADPRC 1 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Daratumumab biosimilar, Whole mAb, Anti-CD38 Antibody: Anti-ADPRC1/ADPRC 1 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Daratumumab, sold under the brand name Darzalex, is an anti-cancer medication. It binds to CD38, which is overexpressed in multiple myeloma cells. Daratumumab was originally developed by Genmab, but it is now being jointly developed by Genmab along with the Johnson & Johnson subsidiary Janssen Biotech, which acquired worldwide commercialization rights to the drug from Genmab.
| Products Name (INN Index) | Pre-Made Daratumumab biosimilar, Whole mAb, Anti-CD38 Antibody: Anti-ADPRC1/ADPRC 1 therapeutic antibody |
|---|---|
| INN Name | Daratumumab |
| Target | CD38 |
| Format | Whole mAb |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Approved |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2009 |
| Year Recommended | 2010 |
| Conditions Approved | Multiple myeloma |
| Conditions Active | Amyloid light-chain amyloidosis,Acute myeloid leukaemia,Chronic lymphocytic leukaemia,Diffuse large B cell lymphoma,Follicular lymphoma,Mantle-cell lymphoma,Myelodysplastic syndromes,Precursor B-cell |
| Conditions Discontinued | Non-small cell lung cancer |
| Development Tech | Medarex HuMAb Mouse |
| Previous Name | NA |
| Gm Offical Target Name | CD38 |
| Package |
