Pre-made Pepinemab benchmark antibody ( Whole mAb, anti-SEMA4D therapeutic antibody, Anti-A8/BB18/C9orf164/CD100/COLL4/GR3/M-sema-G/SEMAJ/coll-4 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Pepinemab biosimilar, Whole mAb, Anti-SEMA4D Antibody: Anti-A8/BB18/C9orf164/CD100/COLL4/GR3/M-sema-G/SEMAJ/coll-4 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Pepinemab is a humanised IgG4 monoclonal antibody against the semaphorin 4D (SEMA4D; CD100), being developed by Vaccinex for the treatment of multiple cancers, Alzheimer’s disease and Huntington’s disease.
| Products Name (INN Index) | Pre-Made Pepinemab biosimilar, Whole mAb, Anti-SEMA4D Antibody: Anti-A8/BB18/C9orf164/CD100/COLL4/GR3/M-sema-G/SEMAJ/coll-4 therapeutic antibody |
|---|---|
| INN Name | Pepinemab |
| Target | SEMA4D |
| Format | Whole mAb |
| Derivation | NA |
| Species Reactivity | Human |
| CH1 Isotype | IgG4 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2018 |
| Year Recommended | 2019 |
| Companies | Bristol-Myers Squibb,Children's Oncology Group,Emory University,Merck KGaA,National Cancer Institute (USA),Teva Pharmaceutical Industries,UCLAs Jonsson Comprehensive Cancer Center,Vaccinex |
| Conditions Approved | NA |
| Conditions Active | Huntington's disease,Non-small cell lung cancer,Osteosarcoma,Solid tumours,Colorectal cancer,Head and neck cancer,Malignant melanoma,Pancreatic cancer |
| Conditions Discontinued | Multiple sclerosis |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | SEMA4D |
| Package |
