Pre-made Setrusumab benchmark antibody ( Whole mAb, anti-SOST therapeutic antibody, Anti-CDD/DAND6/VBCH Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Setrusumab biosimilar, Whole mAb, Anti-SOST Antibody: Anti-CDD/DAND6/VBCH therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Setrusumab is a fully human anti-sclerostin IgG2 monoclonal antibody, being developed by Mereo Biopharma, for the treatment of osteogenesis imperfecta.
| Products Name (INN Index) | Pre-Made Setrusumab biosimilar, Whole mAb, Anti-SOST Antibody: Anti-CDD/DAND6/VBCH therapeutic antibody |
|---|---|
| INN Name | Setrusumab |
| Target | SOST |
| Format | Whole mAb |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IgG2 |
| VD LC | Lambda |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2017 |
| Year Recommended | 2018 |
| Companies | MorphoSys,Novartis,Mereo BioPharma |
| Conditions Approved | NA |
| Conditions Active | Osteogenesis imperfecta |
| Conditions Discontinued | Hypophosphatasia,Postmenopausal osteoporosis |
| Development Tech | MorphoSys HuCAL Phage Display |
| Previous Name | NA |
| Gm Offical Target Name | SOST |
| Package |
