Pre-made Spartalizumab benchmark antibody ( Whole mAb, anti-PDCD1/PD-1 therapeutic antibody, Anti-CD279/PD1/SLEB2/hSLE1 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Spartalizumab biosimilar, Whole mAb, Anti-PDCD1/PD-1 Antibody: Anti-CD279/PD1/SLEB2/hSLE1 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Spartalizumab (INN; development code PDR001) is a monoclonal antibody that is being investigated for melanoma.
| Products Name (INN Index) | Pre-Made Spartalizumab biosimilar, Whole mAb, Anti-PDCD1/PD-1 Antibody: Anti-CD279/PD1/SLEB2/hSLE1 therapeutic antibody |
|---|---|
| INN Name | Spartalizumab |
| Target | PDCD1 |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG4 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2017 |
| Year Recommended | 2018 |
| Companies | Asan Medical Center,Dana-Farber Cancer Institute,Novartis,Novartis Oncology,Palobiofarma,Seoul National University Hospital |
| Conditions Approved | NA |
| Conditions Active | Malignant melanoma,Breast cancer,Colorectal cancer,Diffuse large B cell lymphoma,Gastric cancer,Nasopharyngeal cancer,Non-small cell lung cancer,Solid tumours,Acute myeloid leukaemia,Cancer,Liver can |
| Conditions Discontinued | Neuroendocrine tumours |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | PDCD1 |
| Package |
