Pre-made Tomuzotuximab benchmark antibody ( Whole mAb, anti-EGFR therapeutic antibody, Anti-ERBB/ERRP/HER1/mENA/ERBB1/PIG61/NISBD2 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Tomuzotuximab biosimilar, Whole mAb, Anti-EGFR Antibody: Anti-ERBB/ERRP/HER1/mENA/ERBB1/PIG61/NISBD2 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Tomuzotuximab (previously known as CetuGEX) is a novel immune-enhanced monoclonal antibody (mAb) against the epidermal growth factor receptor (EGFR). It is a glycoengineered second generation antibody of cetuximab produced in the human GlycoExpress expression system (Glycotope).
| Products Name (INN Index) | Pre-Made Tomuzotuximab biosimilar, Whole mAb, Anti-EGFR Antibody: Anti-ERBB/ERRP/HER1/mENA/ERBB1/PIG61/NISBD2 therapeutic antibody |
|---|---|
| INN Name | Tomuzotuximab |
| Target | EGFR |
| Format | Whole mAb |
| Derivation | Chimeric (Mouse/Human) |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | 6au5:DC:BA/6axp:BA:DC/6ayn:BA:DC/6azk:DC:BA/6azl:BA:DC/5i76:DC:BA/1yy8:DC:BA/5th2:DC:BA/5f88:DC:BA/5hyq:DC:BA/5ir1:DC:BA/5ivz:DC:BA/5iv2:DC:BA/5t1k:DC:BA/5t1l:DC:BA/5id0:DC:BA/5id1:DC:BA/5euk:DC:BA/5 |
| 95-98% SI Structure | 5gz0:BA:DC/6arp:BA:DC/6aru:CB |
| Year Proposed | 2016 |
| Year Recommended | 2017 |
| Companies | Glycotope |
| Conditions Approved | NA |
| Conditions Active | Head and neck cancer,Colorectal cancer,Gastric cancer,Non-small cell lung cancer,Renal cancer,Solid tumours |
| Conditions Discontinued | NA |
| Development Tech | GlycoExpress Technology |
| Previous Name | NA |
| Gm Offical Target Name | EGFR |
| Package |
