Pre-made Vixarelimab benchmark antibody ( Whole mAb, anti-OSMR therapeutic antibody, Anti-IL-31R-beta/IL-31RB/OSMRB/OSMRbeta/PLCA1 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Vixarelimab biosimilar, Whole mAb, Anti-OSMR Antibody: Anti-IL-31R-beta/IL-31RB/OSMRB/OSMRbeta/PLCA1 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Vixarelimab is an investigational fully-human monoclonal antibody that targets OSMR¦Â, which mediates signaling of interleukin-31 (IL-31) and oncostatin M (OSM), two key cytokines implicated in pruritus, inflammation and fibrosis.
| Products Name (INN Index) | Pre-Made Vixarelimab biosimilar, Whole mAb, Anti-OSMR Antibody: Anti-IL-31R-beta/IL-31RB/OSMRB/OSMRbeta/PLCA1 therapeutic antibody |
|---|---|
| INN Name | Vixarelimab |
| Target | OSMR |
| Format | Whole mAb |
| Derivation | NA |
| Species Reactivity | Human |
| CH1 Isotype | IgG4-G1 |
| VD LC | Lambda |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2020 |
| Year Recommended | NA |
| Companies | Kiniksa Pharmaceuticals |
| Conditions Approved | NA |
| Conditions Active | Prurigo nodularis,Pruritus,Atopic dermatitis |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | OSMR |
| Package |
