Pre-made Vadastuximab Talirine benchmark antibody (Whole mAb ADC, anti-CD33 therapeutic antibody, Anti-SIGLEC-3/SIGLEC3/p67 Antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-made Vadastuximab Talirine benchmark antibody (Whole mAb ADC, anti-CD33 therapeutic antibody, Anti-SIGLEC-3/SIGLEC3/p67 Antibody) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Vadastuximab talirine or SGN-CD33A is an antibody-drug conjugate or ADC directed to CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. The trial drug, being developed by Seattle Genetics and was in clinical trials for the treatment of acute myeloid leukemia (AML).[1][2]
| Products Name (INN Index) | Pre-Made Vadastuximab Talirine Biosimilar, Whole Mab Adc, Anti-Cd33 Antibody: Anti-SIGLEC-3/SIGLEC3/p67 therapeutic antibody Drug Conjugate |
|---|---|
| INN Name | vadastuximab talirine |
| Target | CD33 |
| Format | Whole mAb ADC |
| Derivation | Chimeric |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 – kappa |
| VD LC | IgG1 – kappa |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Seattle genetics, Inc. (Bothell WA USA) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | CD33 |
| Package |
