Pre-made Biciromab benchmark antibody (Radiolabelled antibody, anti-fibrin II therapeutic antibody) for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-made Biciromab benchmark antibody (Radiolabelled antibody, anti-fibrin II therapeutic antibody) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Indium (111In) biciromab (INN, trade name FibriScint, developed by Centocor) was a drug targeting fibrin, a protein involved in the clotting of blood.[1] It was the Fab’ fragment of a mouse monoclonal antibody labelled with the radioisotope indium-111 for the diagnosis of thromboembolism,[2] but was withdrawn during clinical trials.[3]
| Products Name (INN Index) | Pre-Made Biciromab Biosimilar, Radiolabelled Antibody: Anti-Fibrin Ii therapeutic antibody |
|---|---|
| INN Name | biciromab |
| Target | fibrin II |
| Format | Radiolabelled antibody |
| Derivation | Mus musculus |
| Species Reactivity | Human |
| CH1 Isotype | Fab – G1 – kappa |
| VD LC | Fab – G1 – kappa |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Centocor?Inc. (Horsham PA USA) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | fibrin II |
| Package |
