Pre-Made Clervonafusp Alfa Biosimilar, Fusion Protein targeting SLC29A2/ENT2 fused with human GAA (glucosidase alpha, acid, lysosomal alpha-glucosidase )(Pr67-952) (1:2) Enzyme substitute: Recombinant therapeutic protein targeting DER12/HNP36 for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Clervonafusp Alfa Biosimilar, Fusion Protein targeting SLC29A2/ENT2 fused with human GAA (glucosidase alpha, acid, lysosomal alpha-glucosidase )(Pr67-952) (1:2) Enzyme substitute: Recombinant therapeutic protein targeting DER12/HNP36 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Clervonafusp Alfa is consisting of immunoglobulin G1-kappa, cell-penetrating humanized Fab fragment targeting the equilibrative nucleoside transporter 2 (ENT2), fused with a human lysosomal ¦Á-glucosidase fragment, glycoform alfa. It is used to treat Pompe disease.
| Products Name (INN Index) | Pre-Made Clervonafusp Alfa Biosimilar, Fusion Protein targeting SLC29A2/ENT2 fused with human GAA (glucosidase alpha, acid, lysosomal alpha-glucosidase )(Pr67-952) (1:2) Enzyme substitute: Recombinan |
|---|---|
| INN Name | clervonafusp alfa |
| Target | SLC29A2 |
| Format | Fusion Protein |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | F(ab')2 – G1 – kappa |
| VD LC | F(ab')2 – G1 – kappa |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Valerion Therapeutics,?LLC. (Concord MA USA) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | SLC29A2 |
| Package |
