Pre-Made Lepunafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with human IDUA (iduronidase, alpha-L-) isoform 1 via a peptidyl linker: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Lepunafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with human IDUA (iduronidase, alpha-L-) isoform 1 via a peptidyl linker: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Lepunafusp alfa is a blood-brain-barrier-penetrating form of recombinant human alpha-L-iduronidase fused to the alpha-L-iduronidase anti-transferrin receptor antibody Fab as pabinafusp alfa. Human alpha-L-iduronidase deficiency causes lysosomal storage disease mucopolysaccharidosis type I which leads to disrupted glycosaminoglycan catabolism.
| Products Name (INN Index) | Pre-Made Lepunafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with human IDUA (iduronidase, alpha-L-) isoform 1 via a peptidyl linker: Recombinant therapeutic protein targeting CD71/IMD46/ |
|---|---|
| INN Name | lepunafusp alfa |
| Target | TFRC |
| Format | Fusion Protein |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | F(ab')2 – G1 – kappa |
| VD LC | F(ab')2 – G1 – kappa |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | JCR Pharmaceuticals Co.,?Ltd (Ashiya Japan) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | TFRC |
| Package |
