GMP-BioFcR-ag-007
$5,990.00 – $293,000.00
Human Fc gamma receptor IIA (FcγRIIA, CD32a, R131) His+Avi (Biotinylated) is used to measure the affinity of antibodies for it. The Fc receptor binding assay (Competitive ELISA immunoassay, SRP assay or BLI assay) plays a vital role in the development of therapeutic antibodies.
GeneMedi provides Human Fc gamma receptor IIA (FcγRIIA, CD32a, R131) His+Avi (Biotinylated). The receptor has been classified based on its affinity for IgG1, IgG2, IgG3, IgG4. The Fc receptor is expressed on many immune cells and binds to the specific immunoglobulin, then modulating the immune response.
| Products Name1 | GMP-BioFcR-ag-007-1:Human Fc gamma receptor IIA (FcγRIIA, CD32a, R131) His+Avi |
|---|---|
| Products Name2 | GMP-BioFcR-ag-007-2:Human Fc gamma receptor IIA (FcγRIIA, CD32a, R131) His+Avi (Biotinylated) |
| Isotype | Fc gamma receptor IIA (FcγRIIA, CD32a) |
| Receptor name | |
| Species | Human |
| Principal antibody ligand | IgG1, IgG2, IgG3, IgG4 |
| Major role | Activation |
| Effect following binding to antibody | ADCC, ADCP |
| WT/Mutation | Mutation |
| Mutant variants functions vs WT | reduced affinity to IgG2 |
| Fc Modifications or Mutations (Reduced effector function) | LE (ADCC),LALA(ADCC, ADCP,),LALA-PG (ADCP),TM,DA (ADCC, ADCP),GRLR (ADCC), IgG2/G4, IgG2m4 (ADCC, ADCP),Gly237Ala (ADCP),Glu318Ala (ADCP), Glu233Pro, IgG2σ (ADCC, ADCP), IgG1σ(ADCC), IgG4 PAA (ADCC |
| Fc Modifications or Mutations (Enhanced effector function) | IgG1/IgA2 (ADCC), GASDALIE (ADCC), GA (ADCP), DAE (ADCC, ADCP), variant 18 (ADCC), IgGA (ADCC, ADCP) |
| Application | Antibody Fc&Fc Receptor binding affinity assay (Competitive ELISA immunoassay, Biacore-based SRP assay or BLI assay) |
| Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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