Category Archives: Biologics

Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list

Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. […]

Functional assay for neutralizing antibodies (NAb) discovery–Pseudotype virus (psedovirus, PSV) based and Neutralization Assays

The globalization of the world’s economies, accompanied by increasing international travel, changing climates, altered human behaviour and demographics is leading to the emergence of different viral diseases, many of which are highly pathogenic and hence are considered of great public and animal health importance. To undertake basic research and therapeutic development, many of these viruses […]

FDA approved neutralizing antibodies (NAb)

Monoclonal antibodies (mAbs) against bacterial infections are more effective way to treat the antibiotic resistant strains. The antibacterial mAbs have several advantages such as reducing the antibiotic toxicity, treatment time and disease complications. there are numerous mAb products are under development for a range of infectious diseases. Currently, GeneMedi offers mAbs against gram negative bacteria, […]

Toxin A neutralizing antibodies (NAb)

Clostridium difficile continues to be one of the most prevalent hospital-acquired bacterial infections in the developed world. Alternative approaches under investigation to combat the anaerobic Gram-positive bacteria include fecal transplantation therapy, vaccines, and antibody-based immunotherapies. Inhibitory antibodies that recognize the primary C. difficilevirulence factors, toxin A and toxin B, are the most popular passive immunotherapies under investigation. […]

Shiga toxins (Stxs) neutralizing antibodies (NAb)

Shiga toxins (Stxs) are cytotoxic proteins secreted by Shigella dysenteriae 1 and some serogroups of Escherichia coli (called Stx1 in E. coli). Shiga toxin producing E. coli (STEC) are foodborne pathogens that may colonize and damage the human colon to access to the bloodstream and damage the organs such as kidney and brain. Presently, there […]

Blog | Diagnoctic Technical Articles

Blog | Diagnostic Technical Articles 2019 nCoV (SARS CoV2 coronavirus) Spike trimer (P2-mutant, S1/S2 cleavage site(furin cleavage sequence)-mutant, trimerization modified) The world is in midst of the COVID-19 pandemic caused by SARS-CoV-2 (2019nCoV) infection. The Spike protein (S-protein) of SARS-CoV-2 (2019nCoV) mediates receptor (ACE2) binding and cell entry and is the dominant target of the […]